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Magnetic Resonance Perfusion Imaging: A new method for localizing regions of brain dysfunction associated with specific lexical impairments?

Hillis, Argye E. and Wang, Paul and Barker, Peter and Beauchamp, Norman and Gordon, Barry and Wityk, Robert
Magnetic Resonance Perfusion Imaging: A new method for localizing regions of brain dysfunction associated with specific lexical impairments?. Aphasiology, 14(5-6), 2000, pages 471-483.

Abstract

We investigated correlations between lexical impairments and regional infarction versus hypoperfusion in hyperacute stroke (within 24 hours of onset). Seven patients with hyperacute dominant hemisphere stroke underwent a battery of lexical tasks, and investigational MRI techniques of Diffusion-Weighted Imaging (DWI) and Magnetic Resonance Perfusion Imaging (MRPI). Lexical performance was a function of regional hypoperfusion (on MRPI) rather than region of (probably) completed infarct (on DWI). Strong correlations were found between: accuracy in auditory word comprehension and volume of left temporal and parietal hypoperfusion, and accuracy of naming and left parietal hypoperfusion. Frequent errors in repetition were associated with left temporal and/or left frontal hypoperfusion, but the volume of infarct in these areas was not significantly correlated with the rate of repetition errors. Results of this preliminary study indicate that MRPI is a promising tool for investigating the regions of hypoperfused (dysfunctional, but not infarcted) brain tissue associated with specific language impairments in hyperacute stroke.

EPrint Type:Journal (Paginated)
Keywords:ELECTRICAL-STIMULATION; DIFFUSION; APHASIA; STROKE; COMPREHENSION; TOMOGRAPHY; INFARCTION; PLASTICITY; DEFICITS; LANGUAGE
Subjects:UNSPECIFIED
ID Code:1162
Conference:Clinical Aphasiology Conference: Clinical Aphasiology Conference (1999 : 29th : Key West, FL : June 1999)
Conference Date:June 1999
Publisher:Taylor & Francis
Publication:Aphasiology
Volume:14
Number:5-6
Pages:471-483
Publication Location:London
ISSN:1464-5041
Alternative Locations:http://taylorandfrancis.metapress.com/openurl.asp?genre=article&issn=0268-7038&volume=14&issue=5&spage=471, http://taylorandfrancis.metapress.com/openurl.asp?genre=article&id=doi:10.1080/026870300401252
Additional Information:Access to Full Text is subject to the Publisher's access restrictions