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A double-blind, placebo-controlled study of pharmacological and behavioural treatment of lexical-semantic deficits in aphasia

McNeil, M. R. and Doyle, P. J. and Spencer, K. A. and Goda, A. J. and Flores, D. and Small, S. L.
A double-blind, placebo-controlled study of pharmacological and behavioural treatment of lexical-semantic deficits in aphasia. Aphasiology, 11(4-5), 1997, pages 385-400.

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Abstract

This investigation replicated and extended an earlier study of naming disorders (McNeil. et al. 1995) by administering a placebo and pharmacological agents (d-amphetamine and selegiline) in the presence and absence of a behavioural intervention termed lexical-semantic activation inhibition therapy (L-SAIT) to examine their effects on naming performance in two adults with stroke-induced aphasia. Results revealed acquisition and maintenance effects of L-SAIT on targeted lexical items, no effects of placebo or active pharmacological agents in the absence of L-SAIT, and no differential effects between placebo + L-SAIT and pharmacological agents + L-SAIT. Thus, positive treatment effects were attributed to L-SAIT. Generalization to untrained items within and across form class was not observed, nor was generalization to measures of informativeness of connected speech. Subject 1 evidenced improvement on the Rapid Automatized Naming Test (Denckla and Rudel 1976).

EPrint Type:Journal (Paginated)
Keywords:AMPHETAMINE
Subjects:UNSPECIFIED
ID Code:1107
Conference:Clinical Aphasiology Conference: Clinical Aphasiology Conference (1996 : 26th : Newport, RI : June 1996)
Conference Date:June 1996
Publisher:Taylor & Francis
Publication:Aphasiology
Volume:11
Number:4-5
Pages:385-400
Publication Location:London
ISSN:1464-5041
Additional Information:Copyright by Taylor & Francis Ltd. Used with permission.