Neural plasticity and treatment-induced recovery of sentence processing and production in agrammatism

Den Ouden, Dirk-Bart and Bonakdarpour, Borna and Fix, Steve and Garibaldi, Kyla and Parrish, Todd B. and Thompson, Cynthia K. (2009) Neural plasticity and treatment-induced recovery of sentence processing and production in agrammatism. [Clinical Aphasiology Paper]

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Abstract

Six agrammatic speakers were trained on production and processing of object-relative sentence structures, resulting in generalization to less complex sentence structures. The acquired structure-building process reflected by this generalization was shown to be supported by changes in neuronal activation patterns underlying syntactic task execution, as measured with pre and post training functional MRIs. The most prominent neuronal activity upregulation was seen in posterior temporoparietal cortical areas, outside of the core network activated in a group of healthy control subjects during complex syntactic processing.

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